HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 8-Cyano-1-cyclopropyl-6-fluoro-7-((1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]non-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine | HCID 15069982 | — |
| Reactant | 7-Chloro-8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15347191 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-Cyano-1-cyclopropyl-6-fluoro-7-((1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]non-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 22958372 | — |
Reaction Steps
1.00 g (3.26 mmol) of 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid are stirred under argon at 40-45° C. for 25 hours with 501 mg (3.91 mmol) of (1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]nonane and 0.9 ml of triethylamine in 30 ml of acetonitrile. All volatile components are removed in vacuo and the residue is recrystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432948B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-c194f68c8e2b4d288a91e3c40c9adc5b |
| Source note | uspto-grants-2002_08 |