HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanediamine, N1,N1,N3-trimethyl- → 2-[N-(3-dimethylaminopropyl)-N-methylamino]-N-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]pyridine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanediamine, N1,N1,N3-trimethyl- | HCID 78302 | — |
| Reactant | 2-chloro-N-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]pyridine-4-carboxamide | HCID 22057950 | — |
| Product | 2-[N-(3-dimethylaminopropyl)-N-methylamino]-N-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]pyridine-4-carboxamide | HCID 22057987 | 56% |
Reaction Steps
Using an analogous procedure to that described in Example 21, 2-chloro-N-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]pyridine-4-carboxamide was reacted with N-(3-dimethylaminopropyl)-N-methylamine to give the title compound in 56% yield; Mass Spectrum: M+H+ 532.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432949B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-2ef282e75c22455c8b05a248439384aa |
| Source note | uspto-grants-2002_08 |