Phenylacetic Acid → HCID 70058699, compound

Participants

Reaction Steps

In a manner similar to example 1, the title compound was prepared by the reaction of 2,3,4,5-tetrahydro-3-methyl-5(R,S)-[[(2S)-2-amino-4-methyl-1-oxopentyl]amino]-2-(1-methylethyl)-1H-2,3-benzodiazepin-1,4-dione with phenylacetic acid. The compound was purified on prep HPLC using the column YMC S5 ODS (20×100 mm) with a flow rate of 40 ml/min and gradient time of 10 min., using the solvent composition of solvent A as 10% MeOH—90% H2O—0.1% TFA, and solvent B as 90% MeOH—10% H2O—0.1% TFA. (70% yield). MS (ESI) 479.22 (M+H); Rf 1.42

Provenance & Evidence