3-Nitrobenzylamine → 2,5-Dichloro-6-methyl 4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine

HRID 2302373Notes

Reaction equation

HRID 2302373 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])([O-:3])=[O:2].[Cl:12][C:13]1[N:14]=[C:15](Cl)[C:16]2[C:21]([Cl:22])=[C:20]([CH3:23])[S:19][C:17]=2[N:18]=1>>[Cl:12][C:13]1[N:14]=[C:15]([NH:8][CH2:7][C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:16]2[C:21]([Cl:22])=[C:20]([CH3:23])[S:19][C:17]=2[N:18]=1

Participants

3

Reactant 2

HCID 1227223-NitrobenzylamineHCID 127242442,4,5-Trichloro-6-methyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184601062,5-Dichloro-6-methyl 4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine

Procedure

Following the procedure of Example 1, the reaction of 3-nitrobenzylamine with 2,4,5-trichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2,5-dichloro-6-methyl 4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-2305a4a508cc40d18d0ac33b6b2a038a
Source dataset
uspto-grants-2002_08
Patent number
US06432950B1

Reaction notes

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