HCID 57466437, compound → HCID 11416372, compound

HRID 230250Notes

Reaction equation

HRID 230250 reaction equation
N1C=CC=CC=1S[C:8](=[O:27])[CH2:9][C:10]1[N:14]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:13]2=[N:12][C:11]=1[C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1.[CH2:28]([Mg]Br)[CH2:29][CH2:30][CH2:31][CH3:32]>>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]2[N:14]([C:10]([CH2:9][C:8](=[O:27])[CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[C:11]([C:20]3[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=3)[N:12]=2)[CH:15]=1

Participants

3

Reactant 2

HCID 57466437HCID 57466437, compoundHCID 178445865HCID 178445865, compound

Product 1

HCID 11416372HCID 11416372, compound

Procedure

Prepared from (6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-thioacetic acid S-pyridin-2-yl ester 1c and pentylmagnesium bromide using a similar procedure described above. 1H NMR (400 MHz, CDCl3) δ 0.81 (t, 3H), 1.17 (m, 6H), 1.51 (m, 2H), 2.28 (s, 3H), 2.37 (s, 3H), 4.04 (s, 2H), 7.00 (d, J=8.4 Hz, 1H), 7.23 (d, J=7.3 Hz, 2H), 7.55 (m, 4H). Mass spectrum m/e 335 (M+).

Sources & evidence

ORD record
ord-deab7ede0bd64266a8d4cd7b97a3466f
Source dataset
uspto-grants-2009_07
Patent number
US07566725B2

Reaction notes

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