HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyanopyridine → 4-Chloro-2-(pyridin-3-yl)-6-nitro-thieno-[2,3-d]-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyanopyridine | HCID 79 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-Thiophenecarboxylic acid, 2-amino-5-nitro-, ethyl ester | HCID 2737608 | — |
| Product | 4-Chloro-2-(pyridin-3-yl)-6-nitro-thieno-[2,3-d]-pyrimidine | HCID 18459973 | — |
Reaction Steps
With the procedure of Example 477, the reaction of 3-cyanopyridine and 2-amino-5-nitro-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-3-yl)-6-nitro-thieno-[2,3-d]-pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432950B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-a3951d70f5f8458dbd164e6b43952444 |
| Source note | uspto-grants-2002_08 |