HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 5-Methylthieno[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 2-amino-4-methylthiophene-3-carboxylate | HCID 521132 | — |
| Reactant | 1,2-Oxazole-5-carbonitrile | HCID 11228764 | — |
| Product | 5-Methylthieno[2,3-d]pyrimidine | HCID 12285728 | — |
Reaction Steps
With the procedure of Example 477, the reaction of 5-cyanoisoxazole and 2-amino-4-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432950B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-0f92715da2aa454a9ac089292160ef3e |
| Source note | uspto-grants-2002_08 |