HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-2-carbonitrile → 6-Methylthieno[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-2-carbonitrile | HCID 7522 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| Product | 6-Methylthieno[2,3-d]pyrimidine | HCID 21793077 | — |
Reaction Steps
With the procedure of Example 477, the reaction of 2-cyanopyridine and 2-amino-5-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-pyridin-2-yl)-6-methyl-thieno-[2,3-d]-pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432950B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-626b4d47b2054053855e76b00ae2e623 |
| Source note | uspto-grants-2002_08 |