HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanopyridine → 4-Chloro-2-(pyridin-4-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanopyridine | HCID 7506 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 2-amino-4,5-dimethyl3-thenoate | HCID 78536 | — |
| Product | 4-Chloro-2-(pyridin-4-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine | HCID 18460494 | — |
Reaction Steps
With the procedure of Example 477, the reaction of 4-cyanopyridine and 2-amino-4,5-dimethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-4-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432950B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-db2b5f88a2c54e55b97ba880490e30ca |
| Source note | uspto-grants-2002_08 |