Benzylamine → 2-(Isoxazol-5-yl)-4-benzylamino-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

HRID 2302714Notes

Reaction equation

HRID 2302714 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[C:11]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[S:21][C:12]=2[N:13]=[C:14]([C:16]2[O:20][N:19]=[CH:18][CH:17]=2)[N:15]=1>>[O:20]1[C:16]([C:14]2[N:15]=[C:10]([NH:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:11]3[CH:23]=[C:22]([C:24]([F:26])([F:27])[F:25])[S:21][C:12]=3[N:13]=2)=[CH:17][CH:18]=[N:19]1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 184600434-Chloro-2-(isoxazol-5-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184604772-(Isoxazol-5-yl)-4-benzylamino-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of benzylamine with 4-chloro-2-(isoxazol-5-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-benzylamino-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-a05442ef31c4484db159f547781a6199
Source dataset
uspto-grants-2002_08
Patent number
US06432950B1

Reaction notes

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