反应详情

A mixture of 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (19.6 g), 10% palladium-carbon (50% moist) (4.0 g) and ethanol (240 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for one hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is recrystallized from ethyl acetate/n-hexane to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (15.9 g).

1. customis subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere
2. customfor one hour
3. customThe catalyst is removed by filtration
4. concentrationthe filtrate is concentrated under reduced pressure
5. customThe residue is recrystallized from ethyl acetate/n-hexane