1,3-Benzodioxole-5-ethanamine → 2-(Isoxazol-5-yl)-4-(3,4-methylenedioxyphenethylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

HRID 2303064Notes

Reaction equation

HRID 2303064 reaction equation
[CH2:1]1[O:12][C:11]2[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][C:3]=2[O:2]1.Cl[C:14]1[C:15]2[C:27]([CH3:28])=[CH:26][S:25][C:16]=2[N:17]=[C:18]([C:20]2[O:24][N:23]=[CH:22][CH:21]=2)[N:19]=1>>[O:24]1[C:20]([C:18]2[N:19]=[C:14]([NH:8][CH2:7][CH2:6][C:5]3[CH:9]=[CH:10][C:11]4[O:12][CH2:1][O:2][C:3]=4[CH:4]=3)[C:15]3[C:27]([CH3:28])=[CH:26][S:25][C:16]=3[N:17]=2)=[CH:21][CH:22]=[N:23]1

Participants

3

Reactant 2

HCID 738741,3-Benzodioxole-5-ethanamineHCID 184601204-Chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184600102-(Isoxazol-5-yl)-4-(3,4-methylenedioxyphenethylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of 3,4-methylenedioxyphenethylamine with 4-chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-(3,4-methylenedioxyphenethylamino)-5-methyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-fc0697b51f3f4456b60b0b63aaaf1d16
Source dataset
uspto-grants-2002_08
Patent number
US06432950B1

Reaction notes

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