Acetyl chloride → Sarcosine piperonyl amide hydrochloride

HRID 2303258Notes

Reaction equation

HRID 2303258 reaction equation
[C:1]([NH2:12])(=[O:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:13]([N:20]([CH2:22][C:23]([OH:25])=[O:24])C)(OC(C)(C)C)=O.C([Cl:29])(=O)C>CO>[ClH:29].[C:1]([NH2:12])(=[O:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[NH:20]([CH2:22][C:23]([OH:25])=[O:24])[CH3:13]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 86586337N-Boc sarcosine piperonylamide

Product 1

HCID 69348013Sarcosine piperonyl amide hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-Boc sarcosine piperonylamide (500 mg, 1.54 mmol) in methanol (10 mL) was treated with acetyl chloride (1 mL). After 45 minutes, all volatiles were removed under reduced pressure to yield sarcosine piperonyl amide hydrochloride (395 mg, quant.) as a sticky solid.

Workup

  1. customall volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-fc28ee949da042319d6fcb45d3ce2054
Source dataset
uspto-grants-2002_08
Patent number
US06432947B1

Reaction notes

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