Benzene → HCID 69348685, compound

HRID 2303261Notes

Reaction equation

HRID 2303261 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)[CH:5]=[CH:6][CH:7]=1.[CH2:13]([O:15][C:16](=[O:25])[CH2:17][C:18](=O)[CH2:19][CH2:20][CH2:21][CH2:22]Cl)[CH3:14].II.[CH:28]1C=CC=CC=1>>[CH2:13]([O:15][C:16](=[O:25])[CH:17]=[CH:18][CH:19]1[CH2:20][CH2:21][CH2:22][CH2:28][N:1]1[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)[CH:3]=1)[CH3:14]

Participants

5

Reactant 4

HCID 241BenzeneHCID 807Iodine2×HCID 3212253-(1H-imidazol-1-yl)anilineHCID 13612450Ethyl 7-chloro-3-oxoheptanoate

Product 1

HCID 69348685HCID 69348685, compoundYield 8%

Procedure

The above synthesis may be carried out as follows: To benzene (20 mL) was added 1-(3-aminophenyl)imidazole (755 mg, 4.7 mmol), 7-chloro-3-oxoheptanoic acid ethyl ester (982 mg, 4.7 mmol), Na2HPO4 (667 mg, 4.7 mmol), I2 (60 mg, 0.23 mmol), and 4 Å molecular sieves (500 mg). After refluxing for 6 hours, more I2 (60 mg) was added. After stirring for 16 hours, the reaction was filtered, the solvent was removed in vacuo, and the residues chromatographed (CH2Cl2/MeOH, 98/2) to give 120 mg (8%) of 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acrylic acid ethyl ester (1H NMR (CDCl3) δ7.85 (s, 1), 7.05-7.50 (m, 6), 4.80 (s, 1), 4.15 (q, 2), 3.45 (t, 2), 2.4 (t, 2), 1.5-1.8 (m, 6), 1.30 (t, 3)). This ester (120 mg, 0.38 mmol) was dissolved in MeOH (20 mL) and reacted with 10% Pd/C (60 mg) and 1 atm of H2. After reacting for 60 hours, the reaction was filtered, the solvent removed in vacuo, and the residue chromatographed (ethyl acetate/hexanes, 1/1) to give 24 mg of 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester (compound of formula (XV)). This ester (24 mg, 0.076 mmol) was dissolved in 5% methanolic NaOH. After stirring for 16 hours, the reaction was acidified with methanolic HCl, the solvent removed in vacuo, and the residue dissolved in DMF. Piperonylamine (1 eq), Hünig's base (2 eq) and HATU (1 eq) were added. After reaction completion the reaction mixture was partitioned with water and ethyl acetate. The organic layer was separated, washed with water, and dried. The solvent was removed in vacuo and the residue was chromatographed (ethyl acetate/MeOH, 98/2) to give 6 mg of the compound of formula (Ibb), N-[(1,3-benzodioxol-5-yl)methyl]-1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetamide: 1H NMR (CDCl3) δ7.80 (s, 1), 7.10-7.30 (m, 4), 6.50-6.70 (m, 5), 5.90 (s, 2), 4.20-4.35 (m, 2), 3.85 (br s, 1), 3.50 (t, 2), 2.95 (d, 1), 2.35-2.55 (m, 2), 1.4-1.9 (m, 6); MS: (419 M+H)+.

Workup

  1. customThe above synthesis
  2. temperatureAfter refluxing for 6 hours
  3. filtrationthe reaction was filtered
  4. customthe solvent was removed in vacuo
  5. customthe residues chromatographed (CH2Cl2/MeOH, 98/2)

Sources & evidence

ORD record
ord-59095ff42620431bac56297c0d71306d
Source dataset
uspto-grants-2002_08
Patent number
US06432947B1

Reaction notes

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