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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2303302Generated: October 31, 2026

1-Hydroxybenzotriazole → HCID 12017517, compound

https://huagongshe.com/reaction/2303302

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-HydroxybenzotriazoleHCID 75771—
Reactant1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
ReactantHCID 18460838HCID 18460838—
ReactantAmmonia dioxaneHCID 66648793—
Solvent1,1-DichloroethaneHCID 6365—
ProductHCID 12017517HCID 12017517—

Reaction Steps

2-Chloro-4-(4-methylanilino)pyrimidine-5-carboxylic acid was treated with HOBt and WSC-HCl in dichloroethane and then, under ice-cooling, allowed to undergo the reaction by adding 0.5 M ammonia-1,4-dioxane solution to obtain 2-(benzotriazol-1-yloxy)-4-(4-methylanilino)pyrimidine-5-carboxamide (light yellow powder).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06432963B1
Source datasetuspto-grants-2002_08
ORD IDord-82a04059c90342c1adf31aeb4b006790
Source noteuspto-grants-2002_08