Ethanol → HCID 18460835, compound

Participants

Reaction Steps

A 0.2 ml portion of hydrazine monohydrate was added to a mixture of 350 mg of 2-[2-(1,3-dioxo-2,3-dihydroisoindol-2-yl)ethyl]amino-4-(3-methylanilino)pyrimidine-5-carboxamide with 10 ml of ethanol, followed by heating under reflux for 4 hours. The reaction mixture was concentrated under a reduced pressure. A chloroform-methanol mixed solution was added to the thus obtained residue, followed by washing with water, 1 M sodium hydroxide aqueous solution and saturated brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated under a reduced pressure, and the resulting residue was recrystallized from ethanol to obtain 140 mg of 2-(2-aminoethoxy)-4-(3-methylanilino)pyrimidine-5-carboxamide (colorless crystals).

Provenance & Evidence