Methanol → HCID 18460824, compound

Participants

Reaction Steps

A 100 mg portion of 10% palladium-carbon powder was added to a mixture of 869 mg of 2-(2-aminoethylamino)-4-(3-benzyloxyanilino)pyrimidine-5-carboxamide with THF, methanol and DMF, followed by stirring at room temperature for 3 days in an atmosphere of hydrogen under ordinary pressure. The reaction mixture was filtered, and the filtrate was concentrated under a reduced pressure. By Ad:. recrystallizing the resulting residue from an ethyl acetate-methanol mixed solvent, 217 mg of 2-(2-aminoethylamino)-4-(3-hydroxyanilino)pyrimidine-5-carboxamide was obtained (light brown solid).

Provenance & Evidence