反应详情

A solution of 6-fluoro-3,4-dihydro-2H-isoquinolin-1-one (3.6 g, 0.022 mole) and hydrazine (17.3 mL, 0.55 mole) was stirred at reflux in dioxane (150 mL) under nitrogen for 48 hours. The reaction mixture was concentrated under vacuo, water added (150 mL), and the product isolated by filtration. The product was thoroughly washed with diethyl ether to give the titled compound quantitatively as a white solid.

1. concentrationThe reaction mixture was concentrated under vacuo, water
2. additionadded (150 mL)
3. customthe product isolated by filtration
4. washThe product was thoroughly washed with diethyl ether