HCID 18461111, compound → HCID 18461117, compound

Participants

Reaction Steps

To a stirred suspension of the amide from Step A (82 mg, 0.195 mmol) in 3 mL tetrahydrofuran was added lithium aluminum hydride (1.0M in tetrahydrofuran, 0.39 mL, 0.39 mmol) dropwise. After refluxing for 3 hours, the reaction was quenched with few drops of saturated Na2SO4, and then solvent was removed in vacuo. Purification by silica gel chromatography afforded the title compound (71 mg, 89%). NMR 1.8(m, 2H), 2.4(s, 6H0, 2.4(m, 4H).

Provenance & Evidence