Formaldehyde → HCID 12050351, compound

Participants

Reaction Steps

To a stirred solution of the product of Step C (21 mg, 0.048 mmol) in 2 mL ethanol was added formaldehyde (37% in H2O, 20 ul, 0.24 mmol), followed by borane-pyridine complex (12 ul, 0.097 mmol). After stirring overnight, the reaction was treated with dimethylaminoethanol (1 mL) and heated for 2 hours. Solvent was removed in vacuo. Purification by prep-TLC afforded the desired product (120 mg, 83%).1.2(d, J=6.3 Hz, 3H), 1.9(m, 1H), 2.1(m, 2H), 2.4(s, 3H), 2.5(m, 1H), 2.7(m, 1H), 3.4(m, 1H), 3.6(m, 1H), 3.8(m, 1H).

Provenance & Evidence