Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2303364Generated: October 31, 2026

FMOC-L-valine → N-[2-(tert-butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-Nalpha-(9-fluorenylmethoxycarbonyl)-L-valine amide

https://huagongshe.com/reaction/2303364

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFMOC-L-valineHCID 688217—
ReactantN-[2-(tert-butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amineHCID 18460594—
ProductN-[2-(tert-butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-Nalpha-(9-fluorenylmethoxycarbonyl)-L-valine amideHCID 86758403—

Reaction Steps

N-[2-(tert-Butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amine (679 mg) and N-(9-fluorenylmethoxycarbonyl)-L-valine (865 mg) were treated in the same manner as in Preparation Example 9 to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06432957B1
Source datasetuspto-grants-2002_08
ORD IDord-50524c34725f4556aeedde0cbb13ac1a
Source noteuspto-grants-2002_08