Fmoc-leucine → N-[2-(tert-butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-Nalpha-(9-fluorenylmethoxycarbonyl)-L-leucine amide

Participants

Role	Name	HCID	Charge
Reactant	Fmoc-leucine	HCID 1549133	—
Reactant	N-[2-(tert-butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amine	HCID 18460594	—
Product	N-[2-(tert-butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-Nalpha-(9-fluorenylmethoxycarbonyl)-L-leucine amide	HCID 86758405	—

Reaction Steps

N-[2-(tert-Butyldimethylsilyloxy)ethyl]-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amine (1.40 g) and N-(9-fluorenylmethoxycarbonyl)-L-leucine (1.16 g) were treated in the same manner as in Preparation Example 9 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06432957B1
Source dataset	uspto-grants-2002_08
ORD ID	ord-e9e12a4c9d844777a549c0f3000eaf80
Source note	uspto-grants-2002_08