(3S)-1-Benzyl-3-(propan-2-yl)piperazine → (S)-2-Isopropylpiperazine
Reaction equation
C([N:8]1[CH2:13][CH2:12][NH:11][C@@H:10]([CH:14]([CH3:16])[CH3:15])[CH2:9]1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[CH:14]([C@H:10]1[CH2:9][NH:8][CH2:13][CH2:12][NH:11]1)([CH3:16])[CH3:15]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 50 °C
Procedure
(3S)-1-(Benzyl)-3-isopropylpiperazine (358 mg) was dissolved in acetic acid (10 mL), and to the solution 10% palladium on carbon (40 mg) was added, and the mixture was then stirred at 50° C. under a hydrogen atmosphere for 4 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:ammonia-saturated methanol=20:1) to obtain the title compound.
Workup
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
- customThe residue was purified by column chromatography on silica gel (chloroform:ammonia-saturated methanol=20:1)
Sources & evidence
- ORD record
- ord-fa1d18231fc54ef1b0d9924549df4c97
- Source dataset
- uspto-grants-2002_08
- Patent number
- US06432957B1
Reaction notes
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