N-Benzylglycine ethyl ester → HCID 69351609, compound

HRID 2303373Notes

Reaction equation

HRID 2303373 reaction equation
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C@H:19]([C:24](O)=[O:25])[C@H:20]([CH2:22][CH3:23])[CH3:21])=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:27]([O:29][C:30](=[O:40])[CH2:31][NH:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:28]>>[CH2:27]([O:29][C:30](=[O:40])[CH2:31][N:32]([C:24](=[O:25])[C@H:19]([C@H:20]([CH2:22][CH3:23])[CH3:21])[NH:18][C:16]([O:15][CH2:14][CH:12]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]2[C:13]1=[CH:1][CH:2]=[CH:3][CH:4]=2)=[O:17])[CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH3:28]

Participants

3

Reactant 2

HCID 80908N-Benzylglycine ethyl esterHCID 2724629N-Fmoc-L-isoleucine

Product 1

HCID 69351609HCID 69351609, compound

Procedure

N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine (1.36 g) and N-(benzyl)glycine ethyl ester (770 mg) were reacted in the same manner as in Preparation Example 52 to obtain the title compound.

Sources & evidence

ORD record
ord-9ff5b76f65bf4f4fa5113dd9c6d2f636
Source dataset
uspto-grants-2002_08
Patent number
US06432957B1

Reaction notes

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