HCID 18461172, compound → HCID 18461160, compound

Participants

Reaction Conditions

Reaction Steps

500 mg (1.2 mmol) of [2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][3-fluoro-4-methoxyphenyl]methanone was dissolved in 6 mL of DMF and 200 mg (2.4 mmol) of NaSEt was added. The reaction was heated to 80° C. for 1.5 hours under a nitrogen atmosphere. The reaction mixture quickly filtered over a silica gel column eluted with CHCl3 to remove the solids and exchange the solvent. The effluent from the column was evaporated to a solid and re-dissolved in EtOAc. The EtOAc solution was chromatographed on a silica gel column eluted with a linear gradient beginning with EtOAc-hexane (3:7) and finishing with EtOAc-hexane (1:1). The appropriate fractions were determined by tlc, combined, and evaporated to dryness. This yielded 200 mg of the title compound as a tan amorphous solid.

Provenance & Evidence