Hydrochloric Acid → HCID 69661060, compound

Participants

Reaction Conditions

Reaction Steps

17.3 g (0.75 mol) of metallic sodium were treated dropwise with 250 ml of absolute ethanol. 75.8 g (0.5 mol) of ethyl isonicotinate and 67.6 g (0.5 mol) of 4-fluorophenylacetonitrile were added to the ethoxide. The reaction mixture was stirred at 100° C. for 15 min. The mixture was then cooled in an ice bath and treated with 600 ml of dist. water. On acidifying to pH 1 using 90 ml of conc. HCl, the title compound deposited as a yellow precipitate. The precipitate was filtered off, washed with dist. water and dried over P2O5 in vacuo. Yield: 85.0 g (62%).

Provenance & Evidence