HCID 18461195, compound → HCID 178503170, compound

HRID 2303438Notes

Reaction equation

HRID 2303438 reaction equation
ClCC1C=C(SC)C=CC=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[NH:22][C:21]([S:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([S:31][CH3:32])[CH:26]=3)=[N:20][C:19]=2[C:33]2[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=2)=[CH:14][CH:13]=1.FC1C=CC(C2C(C3C=CN=CC=3)=NC(=S)N=2)=CC=1>C(O)C>[F:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[NH:22][C:21]([S:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([S:31][CH3:32])[CH:26]=3)=[N:20][C:19]=2[C:33]2[CH:34]=[CH:35][N:36]=[CH:37][CH:38]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 18461195HCID 18461195, compoundHCID 178503165HCID 178503165, compound

Product 1

HCID 178503170HCID 178503170, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-(4-Fluorophenyl)-2-[(3-methylthiophenyl)methylthio]-4-(4-pyridyl)-1H-imidazole 3-Chloromethyl-1-methylthiobenzene (690 mg, 4.1 mmol) is dissolved in 60 ml of absolute ethanol in an argon atmosphere. 5-(4-Fluorophenyl)-4-(4-pyridyl)imidazole-2-thione (1.1 g, 4.1 mmol) is introduced into this initial mixture. The reaction mixture is stirred under reflux for 11 h. The heating is removed and the orange-colored solution is subsequently stirred at RT for 61 h. The yellow precipitate is filtered off and dried. Yield: 1.21 g (73%)

Workup

  1. temperatureunder reflux for 11 h
  2. customThe heating is removed
  3. stirringthe orange-colored solution is subsequently stirred at RT for 61 h
  4. filtrationThe yellow precipitate is filtered off
  5. customdried

Sources & evidence

ORD record
ord-e8477e7d3d1548d8b07800d7e7738a36
Source dataset
uspto-grants-2002_08
Patent number
US06432988B1

Reaction notes

Loading…