Chloroacetonitrile → HCID 69910038, compound

Participants

Reaction Conditions

Reaction Steps

A stirring solution of 11 (6.0 g) in DMF (200 mL) was treated with K2CO3 (6 g) and chloroacetonitrile (6 mL) and heated at 75° C. overnight. The mixture was cooled and partitioned between 1:1 EtOAc/hexanes and H2O. The organic layer was washed with 1 M NaOH, washed with brine, dried (MgSO4), filtered, and evaporated. The residue was triturated with Et2O/hexanes. The resulting solid was collected by filtration giving 6.6 g of 2-cyanomethoxy-4-methanesulfonyl-benzoic acid ethyl ester 12.

Provenance & Evidence