1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole → 1-([1,1'-biphenyl]-2-ylmethyl)-4-hydroxy-2-methyl-1H-indole

Participants

Reaction Steps

By the method used in Example 1, Part D, 1.6 g (4.9 mmol) of 1-([1,1′-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 20 mL of 1M BBr3/CH2Cl2. The crude product was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 841 mg (55% yield) of 1-([1,1′-biphenyl]-2-ylmethyl)-4-hydroxy-2-methyl-1H-indole

Provenance & Evidence