HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole | HCID 10825849 | — |
| Reactant | Boron tribromide dichloromethane | HCID 22277759 | — |
| Product | 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole | HCID 10753503 | 84.2% |
Reaction Steps
By the method used in Example 1, Part D, 1.1 g (4.1 mmol) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16.4 mL of 1M BBr3/CH2Cl2 to give 881 mg (84% yield) of crude 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06433001B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-d4f282d3bb244e4e9d5f7df9110618e4 |
| Source note | uspto-grants-2002_08 |