Isopropylhydroxylamine → alpha-(3,4-Ethylenedioxyphenyl)-N-isopropylnitrone

HRID 2303535Notes

Reaction equation

HRID 2303535 reaction equation
[CH2:1]1[CH2:12][O:11][C:10]2[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=2[O:2]1.[CH:13]([NH:16][OH:17])([CH3:15])[CH3:14]>>[CH2:1]1[CH2:12][O:11][C:10]2[CH:9]=[CH:8][C:5]([CH:6]=[N+:16]([CH:13]([CH3:15])[CH3:14])[O-:17])=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 2

HCID 78763IsopropylhydroxylamineHCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehyde

Product 1

HCID 85336065alpha-(3,4-Ethylenedioxyphenyl)-N-isopropylnitrone

Procedure

The title compound was prepared according to the procedure described in Example 11 using 3,4-ethylenedioxybenzaldehyde and N-isopropylhydroxylamine. The crude produce was purified by column chromatography over silica gel using ethyl acetate as the eluant. The title compound was isolated in 53% yield as a solid. m.p. 108.8° C. (Rf=0.31 on a silica gel plate using EtOAc as the eluant).

Workup

  1. customThe title compound was prepared
  2. customThe crude produce
  3. customwas purified by column chromatography over silica gel

Sources & evidence

ORD record
ord-d6c056e4820c40d4a29fe5bbbd611da9
Source dataset
uspto-grants-2002_08
Patent number
US06433008B1

Reaction notes

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