2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl ester → HCID 57762631, compound

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Reaction Steps

In the same manner as in Example 1, 2-(2,6-dichlorobenzamido)pent-4-enoic acid methyl ester (52.4 mg) was reacted with N-(4-bromophenyl)-N-phenylpyrimidin-2-amine (56.6 mg) to obtain (E)-2-(2,6-dichlorobenzamido)-5-[4-(phenyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester (40.0 mg). Column chromatography (silica gel, eluent: chloroform/cyclohexane=1/1→chloroform) and thin layer chromatography (silica gel, developing solvent: cyclohexane/ethyl acetate=1/2) were used for purification.

Provenance & Evidence