Sodium Hydroxide → HCID 54280196, compound

HRID 2303583Notes

Reaction equation

HRID 2303583 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([F:17])=[C:10]([S:13]([NH2:16])(=[O:15])=[O:14])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)(=O)C>[F:17][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[S:13]([NH2:16])(=[O:15])=[O:14])[NH:4][CH2:5][CH2:6]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 545506451-Acetyl-5-fluoro-2,3-dihydro-1H-indole-6-sulfonic acid amide

Product 1

HCID 54280196HCID 54280196, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3.6 grams-of 1-Acetyl-5-fluoro-2,3-dihydro-1H-indole-6-sulfonic acid amide and 30 ml of 2N sodium hydroxide was heated at 100° C. for 3 hours. The reaction was cooled and the pH was adjusted to 7.0 with acetic acid. The resulting precipitate was filtered to give 3.0 grams of the titled compound.

Workup

  1. temperatureThe reaction was cooled
  2. filtrationThe resulting precipitate was filtered

Sources & evidence

ORD record
ord-4a00dc53345746a38292452bd2287b08
Source dataset
uspto-grants-2002_08
Patent number
US06433009B1

Reaction notes

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