Propionitrile → 2'-Amino-3',5'-dimethylpropiophenone

HRID 2303724Notes

Reaction equation

[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[C:10](=[O:12])[CH3:11].[C:13](#N)CC>>[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[C:10](=[O:12])[CH2:11][CH3:13]

Participants

Reactant 2

HCID 7854Propionitrile

HCID 105831361-(2-Amino-3,5-dimethylphenyl)ethan-1-one

Product 1

HCID 234453522'-Amino-3',5'-dimethylpropiophenone

Procedure

2′-Amino-3′,5′-dimethylpropiophenone was synthesized in the same fashion as for 2′-amino-3′,5′-dimethylacetophenone (Example 39) except that propionitrile was used instead of acetonitrile.

Sources & evidence

ORD record: ord-3fa2960d00724b7e9da41f0240e90fe6
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06432994B1

Reaction notes

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