N-(2-acetyl-4,6-dimethylphenyl)-3-(((4-chloro-3-methyl-5-isoxazolyl)amino)sulfonyl)-2-thiophenecarboxamide → 3-(((4-Chloro-3-methyl-5-isoxazolyl)amino)sulfonyl)-N-(2-isobutyryl-4,6-dimethylphenyl)-2-thiophenecarboxamide

HRID 2303726Notes

Reaction equation

HRID 2303726 reaction equation
C(C1C=C(C)C=C(C)C=1N[C:13]([C:15]1[S:16][CH:17]=[CH:18][C:19]=1[S:20]([NH:23][C:24]1[O:28][N:27]=[C:26]([CH3:29])[C:25]=1[Cl:30])(=[O:22])=[O:21])=[O:14])(=O)C.[NH2:31][C:32]1[C:37]([CH3:38])=[CH:36][C:35]([CH3:39])=[CH:34][C:33]=1[C:40](=[O:44])[CH:41]([CH3:43])[CH3:42]>>[Cl:30][C:25]1[C:26]([CH3:29])=[N:27][O:28][C:24]=1[NH:23][S:20]([C:19]1[CH:18]=[CH:17][S:16][C:15]=1[C:13]([NH:31][C:32]1[C:37]([CH3:38])=[CH:36][C:35]([CH3:39])=[CH:34][C:33]=1[C:40](=[O:44])[CH:41]([CH3:42])[CH3:43])=[O:14])(=[O:21])=[O:22]

Participants

3

Reactant 2

HCID 9934302N-(2-acetyl-4,6-dimethylphenyl)-3-(((4-chloro-3-methyl-5-isoxazolyl)amino)sulfonyl)-2-thiophenecarboxamideHCID 107977972'-Amino-3',5'-dimethyl-2-methylpropiophenone

Product 1

HCID 101637443-(((4-Chloro-3-methyl-5-isoxazolyl)amino)sulfonyl)-N-(2-isobutyryl-4,6-dimethylphenyl)-2-thiophenecarboxamide

Procedure

3-(((4-Chloro-3-methyl-5-isoxazolyl)amino)sulfonyl)-N-(2-isobutyryl-4,6-dimethylphenyl)-2-thiophenecarboxamide was synthesized in the same fashion as for N-(2-acetyl-4,6-dimethylphenyl)-3-(((4-chloro-3-methyl-5-isoxazolyl)amino)sulfonyl)-2-thiophenecarboxamide (Example 39) except that 2′-amino-3′,5′-dimethyl-2-methylpropiophenone was used instead of 2′-amino-3′,5′-dimethylacetophenone.

Sources & evidence

ORD record
ord-ec5f412f48d94ec797bb1ff3643de7c2
Source dataset
uspto-grants-2002_08
Patent number
US06432994B1

Reaction notes

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