HCID 10738841, compound → N-(4-Chloro-3-methyl-5-isoxazolyl)-N-methoxymethyl-3-sulfamoyl-5-methyl-2-thiophenecarboxylic acid chloride
Reaction equation
[Cl:1][C:2]1[C:3]([CH3:22])=[N:4][O:5][C:6]=1[N:7]([CH2:19][O:20][CH3:21])[S:8]([C:11]1[CH:15]=[CH:14][S:13][C:12]=1[C:16]([Cl:18])=[O:17])(=[O:10])=[O:9].Cl[C:24]1C(C)=NOC=1N(COC)S(C1C=C(C)SC=1C(O)=O)(=O)=O>>[Cl:1][C:2]1[C:3]([CH3:22])=[N:4][O:5][C:6]=1[N:7]([CH2:19][O:20][CH3:21])[S:8]([C:11]1[CH:15]=[C:14]([CH3:24])[S:13][C:12]=1[C:16]([Cl:18])=[O:17])(=[O:9])=[O:10]Participants
3
Procedure
N-(4-Chloro-3-methyl-5-isoxazolyl)-N-methoxymethyl-3-sulfamoyl-5-methyl-2-thiophenecarboxylic acid chloride was synthesized in the same fashion as for N-(4-chloro-3-methyl-5-isoxazolyl)-N-methoxymethyl-3-sulfamoyl-2-thiophenecarbonyl chloride (Example 51) except that N-(4-chloro-3-methyl-5-isoxazolyl)-N-methoxymethyl-3-sulfamoyl-5-methyl-2-thiophenecarboxylic acid was used instead of N-(4-chloro-3-methyl-5-isoxazolyl)-N-methoxymethyl-3-sulfamoyl-2-thiophenecarboxylic acid.
Sources & evidence
- ORD record
- ord-528f28a5179d4819aa3e5dc3602f39ad
- Source dataset
- uspto-grants-2002_08
- Patent number
- US06432994B1
Reaction notes
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