HCID 18461446, compound → HCID 77844524, compound

HRID 2303761Notes

Reaction equation

HRID 2303761 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:41]=[CH:40][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=4)=[CH:20][C:19]=3[N:31](C)[C:32](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.Cl.O1CCOCC1>>[N:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[O:24][C:21]1[CH:22]=[CH:23][C:18]2[N:17]=[C:15]([CH2:14][O:13][C:12]3[CH:40]=[CH:41][C:9]([CH2:8][CH:4]4[S:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])=[CH:10][CH:11]=3)[N:31]([CH3:32])[C:19]=2[CH:20]=1

Participants

3

Reactant 2

HCID 18461446HCID 18461446, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 77844524HCID 77844524, compoundYield 67.9%

Procedure

Using 0.37 g of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(pyridin-2-yloxy)phenyl}-N-methylcarbamate and 20 ml of a 4N hydrochloric acid/dioxane solution, reaction and purification were carried out in a similar manner to that described in Example (2-2a), whereby 0.20 g of the title compound were obtained.

Sources & evidence

ORD record
ord-657032862e4649c4a64ff008d478823f
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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