HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18461401, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Diethyl cyanophosphonate | HCID 76257 | — |
| Reactant | 2-(4-((2,4-Dioxothiazolidin-5-YL)methyl)phenoxy)acetic acid | HCID 11323485 | — |
| Reactant | HCID 18461429 | HCID 18461429 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18461401 | HCID 18461401 | 75.1% |
Reaction Steps
Using 1.18 g of t-butyl N-{2-amino-5-[2-(morpholin-4-yl)phenoxy]-phenyl}-N-methylcarbamate, 0.92 g of 4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetic acid, 0.53 g of diethyl cyanophosphonate, 0.33 g of triethylamine and 30 ml of anhydrous tetrahydrofuran, reaction and purification were carried out in a similar manner to Example (2-1), whereby 1.47 g of the desired compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-c13330f7a5734739a114d05f76bea35c |
| Source note | uspto-grants-2002_08 |