HCID 18461401, compound → HCID 77844988, compound

HRID 2303765Notes

Reaction equation

HRID 2303765 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:47]=[CH:46][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[CH:20][C:19]=3[N:37]([CH3:45])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1>Cl.O1CCOCC1>[CH3:45][N:37]1[C:19]2[CH:20]=[C:21]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[N:31]3[CH2:32][CH2:33][O:34][CH2:35][CH2:36]3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:46]=[CH:47][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:10][CH:11]=1

Participants

3

Reactant 1

HCID 18461401HCID 18461401, compound

Product 1

HCID 77844988HCID 77844988, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

Using 1.45 g of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-[2-(morpholin-4-yl)phenoxy]phenyl}-N-methylcarbamate and 20 ml of 4N hydrochloric acid/dioxane, reaction and purification were carried out in a similar manner to Example 2a, whereby 0.94 g of the title compound were obtained.

Sources & evidence

ORD record
ord-09052991c65d44efac51400248395e14
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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