HCID 18461491, compound → HCID 77844526, compound

HRID 2303772Notes

Reaction equation

HRID 2303772 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:41]=[CH:40][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([S:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=4)=[CH:20][C:19]=3[N:31]([CH3:39])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1>Cl.O1CCOCC1>[CH3:39][N:31]1[C:19]2[CH:20]=[C:21]([S:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:40]=[CH:41][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:10][CH:11]=1

Participants

3

Reactant 1

HCID 18461491HCID 18461491, compound

Product 1

HCID 77844526HCID 77844526, compoundYield 39.6%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

In a similar manner to that described in Example (2-2a), a reaction was carried out using t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(pyridin-2-ylthio)phenyl}-N-methylcarbamate (0.63 g) and 4N hydrogen chloride/dioxane (20 ml) and the reaction mixture was purified to give the title compound (0.20 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-d32c736863c24b59b60248300b3df2e0
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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