Hydrogen chloride-ethyl acetate → HCID 88008196, compound

HRID 2303773Notes

Reaction equation

HRID 2303773 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:18][O:19][C:20]1[CH:33]=[CH:32][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[NH:27][C:26]2=[O:31])=[CH:22][CH:21]=1.[ClH:34].C(OCC)(=O)C>>[ClH:34].[ClH:34].[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:18][O:19][C:20]1[CH:33]=[CH:32][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[NH:27][C:26]2=[O:31])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 77844526HCID 77844526, compound

Product 1

HCID 88008196HCID 88008196, compound

Procedure

In a similar manner to that described in Example (2-2b), a reaction was carried out using 5-{4-[1-methyl-6-(pyridine-2-ylthio)-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione (0.20 g) and 4N hydrogen chloride/ethyl acetate (50 ml) and the reaction mixture was purified to give the title compound (0.21 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-f25c32b4a328404aa1ae19b2be7055d7
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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