HCID 18461318, compound → HCID 86758431, compound

HRID 2303779Notes

Reaction equation

HRID 2303779 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:51]=[CH:50][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][C:28]([C:31]56[CH2:40][CH:35]7[CH2:36][CH:37]([CH2:39][CH:33]([CH2:34]7)[CH2:32]5)[CH2:38]6)=[CH:27][CH:26]=4)=[CH:20][C:19]=3[N:41]([CH3:49])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:52].O1CCOCC1>>[ClH:52].[C:31]12([C:28]3[CH:29]=[CH:30][C:25]([O:24][C:21]4[CH:22]=[CH:23][C:18]5[N:17]=[C:15]([CH2:14][O:13][C:12]6[CH:11]=[CH:10][C:9]([CH2:8][CH:4]7[S:3][C:2](=[O:1])[NH:6][C:5]7=[O:7])=[CH:51][CH:50]=6)[N:41]([CH3:49])[C:19]=5[CH:20]=4)=[CH:26][CH:27]=3)[CH2:38][CH:37]3[CH2:39][CH:33]([CH2:34][CH:35]([CH2:36]3)[CH2:40]1)[CH2:32]2

Participants

3

Reactant 2

HCID 18461318HCID 18461318, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758431HCID 86758431, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-[4-(1-adamantyl)phenoxy]phenyl}-N-methylcarbamate (1.82 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at ambient temperature for 29 hours. The solvent of the reaction mixture was evaporated to dryness and to the residue was added ether and the insoluble product was filtered and washed with ether to give the title compound (1.35 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness and to the residue
  2. additionwas added ether
  3. filtrationthe insoluble product was filtered
  4. washwashed with ether

Sources & evidence

ORD record
ord-38dda9579dfa40e7a0a213c9ff64e53a
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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