HCID 18461368, compound → HCID 86758433, compound

HRID 2303785Notes

Reaction equation

HRID 2303785 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:47]=[CH:46][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[CH:20][C:19]=3[N:37](C)[C:38](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:48].O1CCOCC1>>[ClH:48].[CH3:38][N:37]1[C:19]2[CH:20]=[C:21]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:47][CH:46]=1

Participants

3

Reactant 2

HCID 18461368HCID 18461368, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758433HCID 86758433, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(2-phenylphenoxy)phenyl}-N-methylcarbamate (2.33 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at ambient temperature for 20 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was collected by filtration and washed with ethyl acetate to give the title compound (1.87 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate and insoluble product
  3. filtrationwas collected by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-951da15c4b374cd6bf6b319cb03ef33f
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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