Hydrogen chloride-ethyl acetate → HCID 88008013, compound

HRID 2303790Notes

Reaction equation

HRID 2303790 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:10]=[CH:11][C:12]3[N:16]=[C:15]([CH2:17][O:18][C:19]4[CH:32]=[CH:31][C:22]([CH2:23][CH:24]5[S:28][C:27](=[O:29])[NH:26][C:25]5=[O:30])=[CH:21][CH:20]=4)[N:14]([CH3:33])[C:13]=3[CH:34]=2)=[CH:4][CH:3]=1.[ClH:35].C(OCC)(=O)C>>[ClH:35].[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:10]=[CH:11][C:12]3[N:16]=[C:15]([CH2:17][O:18][C:19]4[CH:32]=[CH:31][C:22]([CH2:23][CH:24]5[S:28][C:27](=[O:29])[NH:26][C:25]5=[O:30])=[CH:21][CH:20]=4)[N:14]([CH3:33])[C:13]=3[CH:34]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 88008007HCID 88008007, compound

Product 1

HCID 88008013HCID 88008013, compound

Procedure

In a similar manner to that described in Example (2-2b), a reaction was carried out using 5-{4-[6-(4-hydroxyphenylthio)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione (0.72 g) and 4N hydrogen chloride/ethyl acetate (40 ml) and the reaction mixture was purified to give the title compound (0.63 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-a57b90f6567d4b7483c400d2d036ec14
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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