HCID 18461256, compound → HCID 86758440, compound

HRID 2303794Notes

Reaction equation

HRID 2303794 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:46]=[CH:45][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([C:32]([CH3:35])([CH3:34])[CH3:33])[CH:26]=4)=[CH:20][C:19]=3[N:36](C)[C:37](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:47].O1CCOCC1>>[ClH:47].[C:32]([C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][C:28]=1[OH:31])[O:24][C:21]1[CH:22]=[CH:23][C:18]2[N:17]=[C:15]([CH2:14][O:13][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH:4]4[S:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])=[CH:46][CH:45]=3)[N:36]([CH3:37])[C:19]=2[CH:20]=1)([CH3:34])([CH3:35])[CH3:33]

Participants

3

Reactant 2

HCID 18461256HCID 18461256, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758440HCID 86758440, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3-t-butyl-4-hydroxyphenoxy)phenyl}-N-methylcarbamate (1.75 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at room temperature for 14 hours. The solvent of the reaction mixture was evaporated to dryness and to the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (1.11 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness and to the residue
  2. additionwas added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-132b42244b2747f492741ac456dbf8d2
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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