HCID 18461303, compound → HCID 86758444, compound

HRID 2303798Notes

Reaction equation

HRID 2303798 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:47]=[CH:46][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][C:28]([C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:27][CH:26]=4)=[CH:20][C:19]=3[N:37]([CH3:45])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:48].O1CCOCC1>>[ClH:48].[CH3:45][N:37]1[C:19]2[CH:20]=[C:21]([O:24][C:25]3[CH:26]=[CH:27][C:28]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)=[CH:29][CH:30]=3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:47][CH:46]=1

Participants

3

Reactant 2

HCID 18461303HCID 18461303, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758444HCID 86758444, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(4-phenylphenoxy)phenyl}-N-methylcarbamate (2.39 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at room temperature for 21 hours. The solvent of the reaction mixture was evaporated to dryness and to the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (1.90 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness and to the residue
  2. additionwas added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-aee3b5afada1496489f36e3f4190df06
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

Loading…