HCID 131723431, compound → HCID 131723433, compound

HRID 2303806Notes

Reaction equation

HRID 2303806 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:42]=[CH:41][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([S:24][C:25]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=4)=[CH:20][C:19]=3[N:32](C)[C:33](=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1>Cl.O1CCOCC1>[CH3:33][N:32]1[C:19]2[CH:20]=[C:21]([S:24][C:25]3[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=3)[CH:22]=[CH:23][C:18]=2[N:17]=[C:15]1[CH2:14][O:13][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][CH:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[O:7])=[CH:42][CH:41]=1

Participants

3

Reactant 1

HCID 131723431HCID 131723431, compound

Product 1

HCID 131723433HCID 131723433, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

In a similar manner to that described in Example (2-2a), a reaction was carried out using t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(4-methylthiophenoxy)phenyl}-N-methylcarbamate (2.95 g) and 4N hydrogen chloride/dioxane (60 ml) and the reaction mixture was purified to give the title compound (2.15 g)

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-6e1c8bc785404e04ba44bf1d4953215d
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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