Hydrogen chloride-ethyl acetate → HCID 131723434, compound

HRID 2303807Notes

Reaction equation

HRID 2303807 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([S:11][C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:19][O:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][CH:26]2[S:30][C:29](=[O:31])[NH:28][C:27]2=[O:32])=[CH:23][CH:22]=1.[ClH:35].C(OCC)(=O)C>>[ClH:35].[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([S:11][C:12]3[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:19][O:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][CH:26]2[S:30][C:29](=[O:31])[NH:28][C:27]2=[O:32])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 131723433HCID 131723433, compound

Product 1

HCID 131723434HCID 131723434, compound

Procedure

In a similar manner to that described in Example (2-2b), a reaction was carried out using 5-{4-[1-methyl-6-(4-methylthiophenoxy)-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione (1.15 g) and 4N hydrogen chloride/ethyl acetate (20 ml) and the reaction mixture was purified to give the title compound (1.06 g)

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-608004c6e5214f5d8ebabddd329fa8b7
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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