Hydrogen chloride-ethyl acetate → HCID 88008127, compound

HRID 2303810Notes

Reaction equation

HRID 2303810 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:20][O:21][C:22]1[CH:35]=[CH:34][C:25]([CH2:26][CH:27]2[S:31][C:30](=[O:32])[NH:29][C:28]2=[O:33])=[CH:24][CH:23]=1.[ClH:36].C(OCC)(=O)C>>[ClH:36].[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=3)[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:20][O:21][C:22]1[CH:35]=[CH:34][C:25]([CH2:26][CH:27]2[S:31][C:30](=[O:32])[NH:29][C:28]2=[O:33])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 77844759HCID 77844759, compound

Product 1

HCID 88008127HCID 88008127, compound

Procedure

In a similar manner to that described in Example (2-2b), a reaction was carried out using 5-{4-[1-methyl-6-(4-methoxyphenoxy)-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione (1.8 g) and 4N hydrogen chloride/ethyl acetate (50 ml) and the reaction mixture was purified to give the title compound (1.85 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-76311e5b0419429d86ab764c6998baab
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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