HCID 18461475, compound → HCID 86758449, compound

HRID 2303815Notes

Reaction equation

HRID 2303815 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:48]=[CH:47][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=5)=[CH:27][CH:26]=4)=[CH:20][C:19]=3[N:38]([CH3:46])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:49].O1CCOCC1>>[ClH:49].[CH2:31]([C:28]1[CH:29]=[CH:30][C:25]([O:24][C:21]2[CH:22]=[CH:23][C:18]3[N:17]=[C:15]([CH2:14][O:13][C:12]4[CH:47]=[CH:48][C:9]([CH2:8][CH:4]5[S:3][C:2](=[O:1])[NH:6][C:5]5=[O:7])=[CH:10][CH:11]=4)[N:38]([CH3:46])[C:19]=3[CH:20]=2)=[CH:26][CH:27]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 18461475HCID 18461475, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758449HCID 86758449, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(4-benzylphenoxy)phenyl}-N-methylcarbamate (0.91 g) and 4N hydrogen chloride/dioxane (10 ml) was allowed to stand at ambient temperature for 3 days. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (0.69 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-e871f15b9183469292a218cd47ccc73e
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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